A dynamic association between myosteatosis and liver stiffness: Results from a prospective interventional study in obese patients.

ABSTRACT:

Background & aims

Retrospective cross-sectional studies linked sarcopenia and myosteatosis with metabolic dysfunction-associated fatty liver disease (MAFLD). Here, we wanted to clarify the dynamic relationship between sarcopenia, myosteatosis, and MAFLD.

Methods

A cohort of 48 obese patients was randomised for a dietary intervention consisting of 16 g/day of inulin (prebiotic) or maltodextrin (placebo) supplementation. Before and after the intervention, we evaluated liver steatosis and stiffness with transient elastography (TE); we assessed skeletal muscle index (SMI) and skeletal muscle fat index (SMFI) (a surrogate for absolute fat content in muscle) using computed tomography (CT) and bioelectrical impedance analysis (BIA).

Results

At baseline, sarcopenia was uncomm

SUBMITTER: Nachit M 

PROVIDER: S-EPMC8321935 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature