Efficacy of non-sedating H1-receptor antihistamines in adults and adolescents with chronic cough: A systematic review.

ABSTRACT:

Background

Nasal symptoms frequently coexist in patients with chronic cough, and non-sedating H1-receptor antihistamines (nsH1RAs) are often prescribed for cough management in several countries. However, recommendations on the use of nsH1RAs vary among chronic cough guidelines. This study aimed to examine the efficacy of nsH1RAs over placebos in adolescents or adults with chronic cough or allergic respiratory conditions that may present as chronic cough.

Methods

Electronic databases were searched for studies published until November 2020. Randomized placebo-controlled trials of nsH1RAs reporting cough endpoints in adolescents or adults with chronic cough or cough-associated allergic respiratory conditions (allergic rhinitis, allergic asthma, or atopic cough) were included.

SUBMITTER: Lee JH 

PROVIDER: S-EPMC8322120 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature