Pedigree-based and phylogenetic methods support surprising patterns of mutation rate and spectrum in the gray mouse lemur.

ABSTRACT: Mutations are the raw material on which evolution acts, and knowledge of their frequency and genomic distribution is crucial for understanding how evolution operates at both long and short timescales. At present, the rate and spectrum of de novo mutations have been directly characterized in relatively few lineages. Our study provides the first direct mutation-rate estimate for a strepsirrhine (i.e., the lemurs and lorises), which comprises nearly half of the primate clade. Using high-coverage linked-read sequencing for a focal quartet of gray mouse lemurs (Microcebus murinus), we estimated the mutation rate to be among the highest calculated for a mammal at 1.52 × 10^-8 (95% credible interval: 1.28 × 10^-8-1.78 × 10^-8) mutations/site/generation. Further, we f

SUBMITTER: Campbell CR 

PROVIDER: S-EPMC8322134 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature