Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.

ABSTRACT:

Background

Dysfunctional reward processing is implicated in multiple mental disorders. Novelty seeking (NS) assesses preference for seeking novel experiences, which is linked to sensitivity to reward environmental cues.

Methods

A subset of 14-year-old adolescents (IMAGEN) with the top 20% ranked high-NS scores was used to identify high-NS-associated multimodal components by supervised fusion. These features were then used to longitudinally predict five different risk scales for the same and unseen subjects (an independent dataset of subjects at 19 years of age that was not used in predictive modeling training at 14 years of age) (within IMAGEN, n ≈1100) and even for the corresponding symptom scores of five types of patient cohorts (non-IMAGEN), including drinking (n = 313),

SUBMITTER: Qi S 

PROVIDER: S-EPMC8322149 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature