CD147 regulates antitumor CD8⁺ T-cell responses to facilitate tumor-immune escape.

ABSTRACT: Negative regulation of antitumor T-cell-immune responses facilitates tumor-immune escape. Here, we show that deletion of CD147, a type I transmembrane molecule, in T cells, strongly limits in vivo tumor growth of mouse melanoma and lung cancer in a CD8⁺ T-cell-dependent manner. In mouse tumor models, CD147 expression was upregulated on CD8⁺ tumor-infiltrating lymphocytes (TILs), and CD147 was coexpressed with two immune-checkpoint molecules, Tim-3 and PD-1. Mining publicly available gene-profiling data for CD8⁺ TILs in tumor biopsies from metastatic melanoma patients showed a higher level of CD147 expression in exhausted CD8⁺ TILs than in other subsets of CD8⁺ TILs, along with expression of PD-1 and TIM-3. Additionally, CD147 deletion

SUBMITTER: Chen Y 

PROVIDER: S-EPMC8322173 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature