Identification of the causative gene of a transparent phenotype of juvenile red sea bream Pagrus major.

ABSTRACT: Deformities in cultured fish species may be genetic, and identifying causative genes is essential to expand production and maintain farmed animal welfare. We previously reported a genetic deformity in juvenile red sea bream, designated a transparent phenotype. To identify its causative gene, we conducted genome-wide linkage analysis and identified two single nucleotide polymorphisms (SNP) located on LG23 directly linked to the transparent phenotype. The scaffold on which the two SNPs were located contained two candidate genes, duox and duoxa, which are related to thyroid hormone synthesis. Four missense mutations were found in duox and one in duoxa, with that in duoxa showing perfect association with the transparent phenotype. The mutation of duoxa was suggested to affect the transmembrane

SUBMITTER: Sawayama E 

PROVIDER: S-EPMC8322342 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature