An integrated functional and clinical genomics approach reveals genes driving aggressive metastatic prostate cancer.

ABSTRACT: Genomic sequencing of thousands of tumors has revealed many genes associated with specific types of cancer. Similarly, large scale CRISPR functional genomics efforts have mapped genes required for cancer cell proliferation or survival in hundreds of cell lines. Despite this, for specific disease subtypes, such as metastatic prostate cancer, there are likely a number of undiscovered tumor specific driver genes that may represent potential drug targets. To identify such genetic dependencies, we performed genome-scale CRISPRi screens in metastatic prostate cancer models. We then created a pipeline in which we integrated pan-cancer functional genomics data with our metastatic prostate cancer functional and clinical genomics data to identify genes that can drive aggressive prostate cancer pheno

SUBMITTER: Das R 

PROVIDER: S-EPMC8322386 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature