Ontology of the apelinergic system in mouse pancreas during pregnancy and relationship with β-cell mass.

ABSTRACT: The apelin receptor (Aplnr) and its ligands, Apelin and Apela, contribute to metabolic control. The insulin resistance associated with pregnancy is accommodated by an expansion of pancreatic β-cell mass (BCM) and increased insulin secretion, involving the proliferation of insulin-expressing, glucose transporter 2-low (Ins⁺Glut2^LO) progenitor cells. We examined changes in the apelinergic system during normal mouse pregnancy and in pregnancies complicated by glucose intolerance with reduced BCM. Expression of Aplnr, Apelin and Apela was quantified in Ins⁺Glut2^LO cells isolated from mouse pancreata and found to be significantly higher than in mature β-cells by DNA microarray and qPCR. Apelin was localized to most β-cells by immunohistochemistry alth

SUBMITTER: Strutt B 

PROVIDER: S-EPMC8322410 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature