MuSyC is a consensus framework that unifies multi-drug synergy metrics for combinatorial drug discovery.

ABSTRACT: Drug combination discovery depends on reliable synergy metrics but no consensus exists on the correct synergy criterion to characterize combined interactions. The fragmented state of the field confounds analysis, impedes reproducibility, and delays clinical translation of potential combination treatments. Here we present a mass-action based formalism to quantify synergy. With this formalism, we clarify the relationship between the dominant drug synergy principles, and present a mapping of commonly used frameworks onto a unified synergy landscape. From this, we show how biases emerge due to intrinsic assumptions which hinder their broad applicability and impact the interpretation of synergy in discovery efforts. Specifically, we describe how traditional metrics mask consequential synergisti

SUBMITTER: Wooten DJ 

PROVIDER: S-EPMC8322415 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature