Application Research of Individualized Conditional Reprogramming System to Guide Treatment of Gastric Cancer.

ABSTRACT:

Background

Gastric cancer (GC) is one of the most common causes of malignant tumors in the world. Due to the high heterogeneity of GC and lack of specificity of available chemotherapy regimens, these tumors are prone to resistance, recurrence, and metastasis. Here, we formulated an individualized chemotherapy regimen for GC using a modified individual conditional reprogramming (i-CR) system. We established a primary tumor cell bank of GC cells and completed drug screening in order to realize individualized and accurate GC treatment.

Methods

We collected specimens from 93 surgical or gastroscopy GC cases and established a primary tumor cell bank using the i-CR system and PDX models. We also completed in vitro culture and drug sensitivity screening of the GC cells using

SUBMITTER: Zhao W 

PROVIDER: S-EPMC8322696 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature