Pharmacotherapy for diabetes and stroke risk: Results from ROCKET AF.

ABSTRACT:

Background

Insulin use may be a better predictor of stroke risk and morbidity and mortality than diabetes in patients with atrial fibrillation (AF).

Objectives

Determine if the increased risk of stroke observed in patients with AF and diabetes is restricted to those treated with insulin.

Methods

We analyzed the association between diabetes and treatment and the occurrence of stroke/systemic embolism, myocardial infarction (MI), all-cause death, vascular death, composite outcomes, and bleeding risk in the ROCKET AF trial.

Results

In a cohort of 14,264 patients, there were 40.3% (n = 5746) with diabetes, 5.9% (n = 842) on insulin, 18.9% (n = 2697) on oral medications, and 11.9% (n = 1703) diet-controlled. Compared to those without diabetes, patients with non-insu

SUBMITTER: Ugowe FE 

PROVIDER: S-EPMC8322824 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature