Further Investigations into Rigidity-Activity Relationships in BisQAC Amphiphilic Antiseptics.

ABSTRACT: Thirty-six biscationic quaternary ammonium compounds were efficiently synthesized in one step to examine the effect of molecular geometry of two-carbon linkers on antimicrobial activity. The synthesized compounds showed strong antimicrobial activity against a panel of both Gram-positive and Gram-negative bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). While the linker geometry showed only a modest correlation with antimicrobial activity, several of the synthesized bisQACs are promising potential antiseptics due to good antimicrobial activity (MIC≤2 μM) and their higher therapeutic indices compared to previously reported QACs.

SUBMITTER: Leitgeb AJ 

PROVIDER: S-EPMC8322965 | biostudies-literature | 2020 Apr

REPOSITORIES: biostudies-literature