Proteo-Genomic Analysis Identifies Two Major Sites of Vulnerability on Ebolavirus Glycoprotein for Neutralizing Antibodies in Convalescent Human Plasma.

ABSTRACT: Three clinically relevant ebolaviruses - Ebola (EBOV), Bundibugyo (BDBV), and Sudan (SUDV) viruses, are responsible for severe disease and occasional deadly outbreaks in Africa. The largest Ebola virus disease (EVD) epidemic to date in 2013-2016 in West Africa highlighted the urgent need for countermeasures, leading to the development and FDA approval of the Ebola virus vaccine rVSV-ZEBOV (Ervebo^®) in 2020 and two monoclonal antibody (mAb)-based therapeutics (Inmazeb^® [atoltivimab, maftivimab, and odesivimab-ebgn] and Ebanga^® (ansuvimab-zykl) in 2020. The humoral response plays an indispensable role in ebolavirus immunity, based on studies of mAbs isolated from the antibody genes in peripheral blood circulating ebolavirus-specific human memory B cells. Howe

SUBMITTER: Gilchuk P 

PROVIDER: S-EPMC8322977 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature