Association Between Periconceptional Weight of Maternal Grandmothers and Attention-Deficit/Hyperactivity Disorder in Grandchildren.

ABSTRACT:

Importance

Neurodevelopmental disorders have been proposed to involve alterations to epigenetic regulation, and epigenetic effects may extend to germline cells to affect later generations. Weight status may affect DNA methylation, and maternal weight before and during pregnancy has been associated with offspring DNA methylation as well as attention-deficit/hyperactivity disorder (ADHD).

Objective

To assess whether a woman's weight before and during pregnancy is associated with ADHD in her grandchild.

Design, setting, and participants

This cohort study analyzed data from 19 835 grandmother-mother dyads and 44 720 grandchildren in the Nurses' Health Study II (NHS-II) cohort (2001-2013), a population-based prospective cohort study. Cluster-weighted generalized estimating

SUBMITTER: Yim G 

PROVIDER: S-EPMC8322994 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature