Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity: A Microbiome-Wide Analysis From Population Studies.
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ABSTRACT:
SUBMITTER: Chen Z
PROVIDER: S-EPMC8322996 | biostudies-literature | 2021 Jul
REPOSITORIES: biostudies-literature
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Association of Insulin Resistance and Type 2 Diabetes With Gut Microbial Diversity: A Microbiome-Wide Analysis From Population Studies.
Chen Zhangling Z Radjabzadeh Djawad D Chen Lianmin L Kurilshikov Alexander A Kavousi Maryam M Ahmadizar Fariba F Ikram M Arfan MA Uitterlinden Andre G AG Zhernakova Alexandra A Fu Jingyuan J Kraaij Robert R Voortman Trudy T
JAMA network open 20210701 7
<h4>Importance</h4>Previous studies have indicated that gut microbiome may be associated with development of type 2 diabetes. However, these studies are limited by small sample size and insufficient for confounding. Furthermore, which specific taxa play a role in the development of type 2 diabetes remains unclear.<h4>Objective</h4>To examine associations of gut microbiome composition with insulin resistance and type 2 diabetes in a large population-based setting controlling for various sociodemo ...[more]
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