Measuring resting cerebral haemodynamics using MRI arterial spin labelling and transcranial Doppler ultrasound: Comparison in younger and older adults.

ABSTRACT:

Introduction

Resting cerebral blood flow (CBF) and perfusion measures have been used to determine brain health. Studies showing variation in resting CBF with age and fitness level using different imaging approaches have produced mixed findings. We assess the degree to which resting CBF measures through transcranial Doppler (TCD) and arterial spin labeling (ASL) MRI provide complementary information in older and younger, fit and unfit cohorts.

Methods

Thirty-five healthy volunteers (20 younger: 24 ± 7y; 15 older: 66 ± 7y) completed two experimental sessions (TCD/MRI). Aging and fitness effects within and between imaging modalities were assessed.

Results

Middle cerebral artery blood velocity (MCAv, TCD) was lower and transit time (MRI) slower in older compared with youn

SUBMITTER: Burley CV 

PROVIDER: S-EPMC8323033 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature