A multipurpose brachytherapy catheter to enable intratumoral injection.

ABSTRACT:

Purpose

To create and test a multipurpose brachytherapy catheter prototype enabling intratumoral injection and brachytherapy after a single catheter insertion.

Methods and materials

The design of the prototype consists of an outer tube and an inner syringe tube that can be filled with injectable agent. The outer sheath and inner syringe tube were constructed using polytetrafluoroethylene tubing, and the other components were 3D printed using dental resin and polylactic acid material. To demonstrate functionality, we injected in vitro phantoms with dyed saline. For proof of concept, we demonstrated the potential for the prototype to deliver cell therapy, enhance tumor delineation, deliver tattoo ink for pathology marking, avoid toxicity through local delivery of chemotherapy,

SUBMITTER: Jagodinsky JC 

PROVIDER: S-EPMC8323107 | biostudies-literature | 2021 Jul-Aug

REPOSITORIES: biostudies-literature