Causal effects of education on chronic kidney disease: a Mendelian randomization study.

ABSTRACT:

Background

Poor socio-economic status, including low education attainment, has been reported in chronic kidney disease (CKD) patients. We aimed to investigate the causal effects of education attainment on the risk of CKD.

Methods

The study was an observational cohort study including Mendelian randomization (MR) analysis. First, the clinical association between education attainment years as the exposure and prevalent CKD Stages 3-5 as the outcome was investigated by multivariable logistic regression in 308 741 individuals 40-69 years of age from the UK Biobank. MR analysis was performed with a previously reported genetic instrument from a genome-wide association meta-analysis of education attainment. Two-sample MR was performed with summary statistics for CKD in 567 460 indiv

SUBMITTER: Park S 

PROVIDER: S-EPMC8323131 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature