Multiparametric MRI assessment of renal structure and function in acute kidney injury and renal recovery.

ABSTRACT:

Background

Acute kidney injury (AKI) is associated with a marked increase in mortality as well as subsequent chronic kidney disease (CKD) and end-stage kidney disease. We performed multiparametric magnetic resonance imaging (MRI) with the aim of identifying potential non-invasive MRI markers of renal pathophysiology in AKI and during recovery.

Methods

Nine participants underwent inpatient MRI scans at time of AKI; seven had follow-up scans at 3 months and 1 year following AKI. Multiparametric renal MRI assessed total kidney volume (TKV), renal perfusion using arterial spin labelling, T₁ mapping and blood oxygen level-dependent (BOLD) R₂* mapping.

Results

Serum creatinine concentration had recovered to baseline levels at 1-year post-AKI in all par

SUBMITTER: Buchanan C 

PROVIDER: S-EPMC8323137 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature