Effects of sodium zirconium cyclosilicate on sodium and potassium excretion in healthy adults: a Phase 1 study.

ABSTRACT:

Background

Sodium zirconium cyclosilicate (SZC; formerly ZS-9) is a potassium (K⁺) binder for treatment of hyperkalemia in adults. SZC binds K⁺ in exchange for sodium (Na⁺) or hydrogen (H⁺) in the gastrointestinal tract, conveying potential for systemic absorption of Na⁺.

Methods

This single-center Phase 1 study evaluated the effects of SZC on Na⁺ and K⁺ excretion in healthy, normokalemic adults. During an initial run-in period (Days 1-2), participants started a high K⁺/low Na⁺ diet. After baseline (Days 3-4), SCZ 5 or 10 g once daily (QD) was administered (Days 5-8). The primary endpoint was mean change in urinary Na⁺ excretion from baseline (Days 3-4) to the treatm

SUBMITTER: Nagard M 

PROVIDER: S-EPMC8323143 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature