Listeria monocytogenes upregulates mitochondrial calcium signalling to inhibit LC3-associated phagocytosis as a survival strategy.

ABSTRACT: Mitochondria are believed to have originated ~2.5 billion years ago. As well as energy generation in cells, mitochondria have a role in defence against bacterial pathogens. Despite profound changes in mitochondrial morphology and functions following bacterial challenge, whether intracellular bacteria can hijack mitochondria to promote their survival remains elusive. We report that Listeria monocytogenes-an intracellular bacterial pathogen-suppresses LC3-associated phagocytosis (LAP) by modulation of mitochondrial Ca²⁺ (mtCa²⁺) signalling in order to survive inside cells. Invasion of macrophages by L. monocytogenes induced mtCa²⁺ uptake through the mtCa²⁺ uniporter (MCU), which in turn increased acetyl-coenzyme A (acetyl-CoA) production by pyruvat

SUBMITTER: Li T 

PROVIDER: S-EPMC8323152 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature