Associations of Microvascular Complications With the Risk of Cardiovascular Disease in Type 1 Diabetes.

ABSTRACT:

Objective

We examined whether the presence of microvascular complications was associated with increased subsequent risk of cardiovascular disease (CVD) among participants with type 1 diabetes in the Diabetes Control and Complications Trial and Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) study followed for >35 years.

Research design and methods

Standardized longitudinal data collection included: 1) stereoscopic seven-field retinal fundus photography centrally graded for retinopathy stage and clinically significant macular edema; 2) urinary albumin excretion rate (AER) and estimated glomerular filtration rate (eGFR); 3) cardiovascular autonomic neuropathy (CAN) reflex testing; and 4) adjudicated CVD events, including death f

SUBMITTER: Gubitosi-Klug R 

PROVIDER: S-EPMC8323173 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature