Land Cover of Early-Life Environment Modulates the Risk of Type 1 Diabetes.

ABSTRACT:

Objective

Environmental microbial exposures have been implicated to protect against immune-mediated diseases such as type 1 diabetes. Our objective was to study the association of land cover around the early-life dwelling with the development of islet autoimmunity and type 1 diabetes to evaluate the role of environmental microbial biodiversity in the pathogenesis.

Research design and methods

Association between land cover types and the future risk of type 1 diabetes was studied by analyzing land cover types classified according to Coordination of Information on the Environment (CORINE) 2012 and 2000 data around the dwelling during the first year of life for 10,681 children genotyped for disease-associated HLA-DQ alleles and monitored from birth in the Type 1 Diabetes Predict

SUBMITTER: Nurminen N 

PROVIDER: S-EPMC8323192 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature