Circulating vitamin C concentration and risk of cancers: a Mendelian randomization study.

ABSTRACT:

Background

Circulating vitamin C concentrations have been associated with several cancers in observational studies, but little is known about the causal direction of the associations. This study aims to explore the potential causal relationship between circulating vitamin C and risk of five most common cancers in Europe.

Methods

We used summary-level data for genetic variants associated with plasma vitamin C in a large vitamin C genome-wide association study (GWAS) meta-analysis on 52,018 Europeans, and the corresponding associations with lung, breast, prostate, colon, and rectal cancer from GWAS consortia including up to 870,984 participants of European ancestry. We performed two-sample, bi-directional Mendelian randomization (MR) analyses using inverse-variance-weighted me

SUBMITTER: Fu Y 

PROVIDER: S-EPMC8323227 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature