Multi-function PtCo nanozymes/CdS nanocrystals@graphene oxide luminophores and K₂S₂O₈/H₂O₂ coreactants-based dual amplified electrochemiluminescence immunosensor for ultrasensitive detection of anti-myeloperoxidase antibody.

ABSTRACT:

Background

Anti-myeloperoxidase antibody (anti-MPO) is an important biomarker for anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAVs). However, the complicated operation procedures and insufficient sensitivity of conventional anti-MPO detection methods limit their application in monitoring efficacy of AAVs in clinical diagnosis. Herein, a dual amplified electrochemiluminescence (ECL) immunosensor based on multi-function PtCo nanozymes/CdS nanocrystals@graphene oxide (PtCo/CdS@GO) luminophores and K₂S₂O₈/H₂O₂ coreactants has been fabricated for ultrasensitive detection of anti-MPO.

Results

PtCo/CdS@GO luminophores as novel signal amplification labels and nanocarriers to load rabbit anti-mouse IgG were

SUBMITTER: Yang W 

PROVIDER: S-EPMC8323290 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature