Thymic development of gut-microbiota-specific T cells.

ABSTRACT: Humans and their microbiota have coevolved a mutually beneficial relationship in which the human host provides a hospitable environment for the microorganisms and the microbiota provides many advantages for the host, including nutritional benefits and protection from pathogen infection¹. Maintaining this relationship requires a careful immune balance to contain commensal microorganisms within the lumen while limiting inflammatory anti-commensal responses^1,2. Antigen-specific recognition of intestinal microorganisms by T cells has previously been described^3,4. Although the local environment shapes the differentiation of effector cells^3-5 it is unclear how microbiota-specific T cells are educated in the thymus. Here we show that intestinal coloniza

SUBMITTER: Zegarra-Ruiz DF 

PROVIDER: S-EPMC8323488 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature