Project description:Sex differences in rat adrenal cortex are manifested as larger adrenal volume of cortex and higher corticosterone secretion by females compared with males. The molecular bases of these sex related differences are poorly understood. Therefore we performed microarray studies to demonstrate the effect of testosterone and estradiol on the expression of differentially regulated genes in rat adrenal gland.

2017-01-18 | GSE93726 | GEO

Effects of Testosterone and Evoked Resistance Exercise after Spinal Cord Injury (TEREX-SCI): study protocol for a randomised controlled trial.

Project description: Not available

| S-EPMC5387951 | biostudies-literature

Testosterone Replacement, Muscle Strength, and Physical Function.

Project description: Not available

| S-EPMC5924952 | biostudies-literature

Neurophysiology of epidurally evoked spinal cord reflexes in clinically motor-complete posttraumatic spinal cord injury.

Project description: Not available

| S-EPMC8354937 | biostudies-literature

Visceral Adiposity, Inflammation, and Testosterone Predict Skeletal Muscle Mitochondrial Mass and Activity in Chronic Spinal Cord Injury.

Project description: Not available

| S-EPMC8867006 | biostudies-literature

Recovery cycles of posterior root-muscle reflexes evoked by transcutaneous spinal cord stimulation and of the H reflex in individuals with intact and injured spinal cord.

Project description: Not available

| S-EPMC6932776 | biostudies-literature

Transcriptome Profile of Rat Adrenal Evoked by Gonadectomy and Testosterone or Estradiol Replacement.

Project description: Not available

| S-EPMC5309227 | biostudies-literature

Electrically Preconditioned Neural Tissues Direct Circuit Reconstruction for Spinal Cord Repair

Project description:Spinal cord injury (SCI) creates a prohibitive microenvironment that limits the efficacy of neural stem cell (NSC) therapies. We developed electrically preconditioned engineered neural tissues (ENT) to address these limitations through: (1) pre-establishment of functional neural networks in vitro, and (2) enhanced host integration capacity. EGFP-expressing NSCs were differentiated in 3D Matrigel under 150 mV/mm physiological electric fields (EFs) and transplanted into T10 hemisection SCI mice. Outcomes were assessed through: Basso Mouse Scale (BMS) scoring, multiplex immunofluorescence (Nestin/MAP2/GFAP/MBP/Synaptophysin/ChAT), cortical somatosensory/motor evoked potentials (CSEP/CMEP), RNA sequencing and pathway analysis. At 28 days post transplantation, ENT transplanted animals showed significantly higher BMS scores and enhanced CSEP/CMEP amplitudes compared to the NSC suspension group. We conducted comprehensive evaluations of the histological structure and function of EF-preconditioned ENT and the mice that received ENT transplantation: (1) in vitro maturation of ENT: high neuronal differentiation, dense synaptic networks and myelinated axon; (2) in vivo integration: niche-directed migration (graft-derived cells showed central canal (Nestin+ cells) and grey matter (ChAT+ cells) homing), achieved functional synaptic integration and correlated with motor recovery. Mechanistic analysis revealed EF activation of pro-neuronal pathways and gliogenesis suppression. These results demonstrate that EF-preconditioned ENT contributes to structural neural network reconstruction, niche-directed homing, functional synaptic integration and significant motor recovery.

2026-04-01 | GSE318642 | GEO

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