Hydroxyl Radical Generation Through the Fenton-Like Reaction of Hematin- and Catechol-Functionalized Microgels.

ABSTRACT: Hydroxyl radical (^•OH) is a potent reactive oxygen species with the ability to degrade hazardous organic compounds, kill bacteria, and inactivate viruses. However, an off-the-shelf, portable, and easily activated biomaterial for generating ^•OH does not exist. Here, microgels were functionalized with catechol, an adhesive moiety found in mussel adhesive proteins, and hematin (HEM), a hydroxylated Fe³⁺ ion-containing porphyrin derivative. When the microgel was hydrated in an aqueous solution with physiological pH, molecular oxygen in the solution oxidized catechol to generate H₂O₂, which was further converted to ^•OH by HEM. The generated ^•OH was able to degrade organic dyes, including orange II and malachite green.

SUBMITTER: Forooshani PK 

PROVIDER: S-EPMC8323869 | biostudies-literature | 2020 Oct

REPOSITORIES: biostudies-literature