Staging liver fibrosis after severe yellow fever with ultrasound elastography in Brazil: A six-month follow-up study.

ABSTRACT:

Background

Yellow fever (YF) is a hemorrhagic disease caused by an arbovirus endemic in South America, with recent outbreaks in the last years. Severe cases exhibit fulminant hepatitis, but there are no studies regarding its late-term effects on liver parenchyma. Thus, the aim of this study was to determine the frequency and grade of liver fibrosis in patients who recovered from severe YF and to point out potential predictors of this outcome.

Methodology/principal findings

We followed-up 18 patients who survived severe YF during a recent outbreak (January-April 2018) in Brazil using ultrasound (US) with shear-wave elastography (SWE) at 6 months after symptoms onset. No patient had previous history of liver disease. Median liver stiffness (LS) was 5.3 (4.6-6.4) kPa. 2 (11.1%)

SUBMITTER: Neves YCS 

PROVIDER: S-EPMC8323872 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature