Unraveling Deep Gray Matter Atrophy and Iron and Myelin Changes in Multiple Sclerosis.

ABSTRACT:

Background and purpose

Modifications of magnetic susceptibility have been consistently demonstrated in the subcortical gray matter of MS patients, but some uncertainties remain concerning the underlying neurobiological processes and their clinical relevance. We applied quantitative susceptibility mapping and longitudinal relaxation rate relaxometry to clarify the relative contribution of atrophy and iron and myelin changes to deep gray matter damage and disability in MS.

Materials and methods

Quantitative susceptibility mapping and longitudinal relaxation rate maps were computed for 91 patients and 55 healthy controls from MR images acquired at 3T. Applying an external model, we estimated iron and myelin concentration maps for all subjects. Subsequently, changes of deep gray

SUBMITTER: Pontillo G 

PROVIDER: S-EPMC8324266 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature