Expansion of CD10^neg neutrophils and CD14⁺HLA-DR^neg/low monocytes driving proinflammatory responses in patients with acute myocardial infarction.

ABSTRACT: Immature neutrophils and HLA-DR^neg/low monocytes expand in cancer, autoimmune diseases and viral infections, but their appearance and immunoregulatory effects on T-cells after acute myocardial infarction (AMI) remain underexplored. We found an expansion of circulating immature CD16⁺CD66b⁺CD10^neg neutrophils and CD14⁺HLA-DR^neg/low monocytes in AMI patients, correlating with cardiac damage, function and levels of immune-inflammation markers. Immature CD10^neg neutrophils expressed high amounts of MMP-9 and S100A9, and displayed resistance to apoptosis. Moreover, we found that increased frequency of CD10^neg neutrophils and elevated circulating IFN-γ levels were linked, mainly in patients with expanded CD4

SUBMITTER: Fraccarollo D 

PROVIDER: S-EPMC8324297 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature