Extracellular-Matrix-Anchored Click Motifs for Specific Tissue Targeting.

ABSTRACT: Local presentation of cancer drugs by injectable drug-eluting depots reduces systemic side effects and improves efficacy. However, local depots deplete their drug stores and are difficult to introduce into stiff tissues, or organs, such as the brain, that cannot accommodate increased pressure. We present a method for introducing targetable depots through injection of activated ester molecules into target tissues that react with and anchor themselves to the local extracellular matrix (ECM) and subsequently capture systemically administered small molecules through bioorthogonal click chemistry. A computational model of tissue-anchoring depot formation and distribution was verified by histological analysis and confocal imaging of cleared tissues. ECM-anchored click groups do not elicit any no

SUBMITTER: Adams MR 

PROVIDER: S-EPMC8324317 | biostudies-literature | 2020 Feb

REPOSITORIES: biostudies-literature