Ontology highlight
ABSTRACT:
SUBMITTER: Adams MR
PROVIDER: S-EPMC8324317 | biostudies-literature | 2020 Feb
REPOSITORIES: biostudies-literature
Adams Mary R MR Moody Christopher T CT Sollinger Jennifer L JL Brudno Yevgeny Y
Molecular pharmaceutics 20191227 2
Local presentation of cancer drugs by injectable drug-eluting depots reduces systemic side effects and improves efficacy. However, local depots deplete their drug stores and are difficult to introduce into stiff tissues, or organs, such as the brain, that cannot accommodate increased pressure. We present a method for introducing targetable depots through injection of activated ester molecules into target tissues that react with and anchor themselves to the local extracellular matrix (ECM) and su ...[more]