Brown adipose tissue is associated with healthier body fat distribution and metabolic benefits independent of regional adiposity.

ABSTRACT: The association of brown adipose tissue (BAT) and body fat distribution and their combined effects on metabolic health in humans remains unknown. Here, we retrospectively identify individuals with and without BAT on ¹⁸F-fluorodeoxyglucose (¹⁸F-FDG) positron emission tomography (PET)/computed tomography (CT) and assemble a propensity score-matched study cohort to compare body fat distribution and determine its role in mediating the benefits of brown fat. We find that BAT is associated with lower amounts of visceral adipose tissue and higher amounts of subcutaneous adipose tissue, resulting in less central obesity. In addition, BAT is independently associated with lower blood glucose and white blood cell count, improved lipids, lower prevalence of type 2 diabetes mellit

SUBMITTER: Wibmer AG 

PROVIDER: S-EPMC8324464 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature