EOMES and IL-10 regulate antitumor activity of T regulatory type 1 CD4⁺ T cells in chronic lymphocytic leukemia.

ABSTRACT: The transcription factor eomesodermin (EOMES) promotes interleukin (IL)-10 expression in CD4⁺ T cells, which has been linked to immunosuppressive and cytotoxic activities. We detected cytotoxic, programmed cell death protein-1 (PD-1) and EOMES co-expressing CD4⁺ T cells in lymph nodes (LNs) of patients with chronic lymphocytic leukemia (CLL) or diffuse large B-cell lymphoma. Transcriptome and flow cytometry analyses revealed that EOMES does not only drive IL-10 expression, but rather controls a unique transcriptional signature in CD4⁺ T cells, that is enriched in genes typical for T regulatory type 1 (T_R1) cells. The T_R1 cell identity of these CD4⁺ T cells was supported by their expression of interferon gamma and IL-10, as w

SUBMITTER: Roessner PM 

PROVIDER: S-EPMC8324479 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature