Brain Correlates of Suicide Attempt in 18,925 Participants Across 18 International Cohorts.

ABSTRACT:

Background

Neuroimaging studies of suicidal behavior have so far been conducted in small samples, prone to biases and false-positive associations, yielding inconsistent results. The ENIGMA-MDD Working Group aims to address the issues of poor replicability and comparability by coordinating harmonized analyses across neuroimaging studies of major depressive disorder and related phenotypes, including suicidal behavior.

Methods

Here, we pooled data from 18 international cohorts with neuroimaging and clinical measurements in 18,925 participants (12,477 healthy control subjects and 6448 people with depression, of whom 694 had attempted suicide). We compared regional cortical thickness and surface area and measures of subcortical, lateral ventricular, and intracranial volumes betwe

SUBMITTER: Campos AI 

PROVIDER: S-EPMC8324512 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature