Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus.

ABSTRACT:

Objective

Systemic lupus erythematosus (SLE) involves kidney damage, and the inflammasome-caspase-1 axis has been demonstrated to promote renal pathogenesis. The present study was designed to explore the function of the Absent in Melanoma 2 (Aim2) protein in SLE.

Methods

Female wild-type Aim2^-/- , Aim2^-/- Ifnar1^-/- , Aim2^-/- Rag1^-/- , and Asc^-/- mice ages 8-10 weeks received 1 intraperitoneal injection of 500 μl pristane or saline, and survival of mice was monitored twice a week for 6 months.

Results

The absence of Aim2, but not Asc, led to enhanced SLE in mice that received pristane treatment. Increased immune cell infiltration and type I interferon (IFN) signatures in the kidneys of Aim2^-/-

SUBMITTER: Lu A 

PROVIDER: S-EPMC8324518 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature