Associations of serum cytokines and chemokines with the risk of incident cancer in a prospective rheumatoid arthritis cohort.

ABSTRACT:

Objectives

We aimed to assess whether serum cytokine/chemokine concentrations predict incident cancer in RA patients.

Methods

Data from cancer-free enrollees in the Veterans Affairs Rheumatoid Arthritis (VARA) Registry were linked to a national VA oncology database and the National Death Index (NDI) to identify incident cancers. Seventeen serum cytokines/chemokines were measured from enrollment serum and an overall weighted cytokine/chemokine score (CK score) was calculated. Associations of cytokines/chemokines with all-site, lung, and lymphoproliferative cancers were assessed in Cox regression models accounting for relevant covariates including age, sex, RA disease activity, and smoking.

Results

In 1216 patients, 146 incident cancers (42 lung and 23 lymphoproliferati

SUBMITTER: England BR 

PROVIDER: S-EPMC8324526 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature