Sex differences in the vascular response to sympathetic activation during acute hypoxaemia.

ABSTRACT:

New findings

What is the central question of this study? Sympathetically mediated vasoconstriction is preserved during hypoxaemia in humans, but our understanding of vascular control comes from predominantly male cohorts. We tested the hypothesis that young women attenuate sympathetically mediated vasoconstriction during steady-state hypoxaemia, whereas men do not? What is the main finding and its importance? Sympathetically mediated vasoconstriction is preserved or even enhanced during steady-state hypoxia in young men, and the peripheral vascular response to sympathetic activation during hypoxaemia is attenuated in young women. These data advance our understanding of sex-related differences in hypoxic vascular control.

Abstract

Activation of the sympathetic nervous system

SUBMITTER: Jacob DW 

PROVIDER: S-EPMC8324557 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature