Mutant IDH1 promotes phagocytic function of microglia/macrophages in gliomas by downregulating ICAM1.

ABSTRACT: Tumor-associated microglia/macrophages (TAMs) are the main innate immune effector cells in malignant gliomas and have both pro- and anti-tumor functions. The plasticity of TAMs is partially dictated by oncogenic mutations in tumor cells. Heterozygous IDH1 mutation is a cancer driver gene prevalent in grade II/III gliomas, and IDH1 mutant gliomas have relatively favorable clinical outcomes. It is largely unknown how IDH mutation alters TAM phenotypes to influence glioma growth. Here we established clinically relevant isogenic glioma models carrying monoallelic IDH1 R132H mutation (IDH1^R132H/WT) and found that IDH1^R132H/WT significantly downregulated immune response-related pathways in glioma cells, indicating an immunomodulation role of mutant IDH1. Co-culturing IDH1

SUBMITTER: Ma D 

PROVIDER: S-EPMC8324572 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature