Duloxetine Exposure During Pregnancy and the Risk of Spontaneous and Elective Abortion: A Danish Nationwide Observational Study.

ABSTRACT:

Background

Depression and antidepressant treatment are widespread among women of childbearing age.

Objective

This study evaluates the association between duloxetine exposure during pregnancy and spontaneous and elective abortions.

Patients and methods

The nationwide, observational study based on register data from Denmark included women with a recorded pregnancy in the birth register or an abortion in the patient register between 2004 and 2016. Duloxetine-exposed women were compared with (1) duloxetine non-exposed, (2) selective serotonin reuptake inhibitor (SSRI)-exposed, (3) venlafaxine-exposed, and (4) women discontinuing duloxetine before pregnancy. Exposure status was based on records of redeemed prescriptions. Cox regression with adjustments and propensity score

SUBMITTER: Ankarfeldt MZ 

PROVIDER: S-EPMC8324661 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature