Genetic and epigenetic factors determining NAFLD risk.

ABSTRACT:

Background

Hepatic steatosis is a common chronic liver disease that can progress into more severe stages of NAFLD or promote the development of life-threatening secondary diseases for some of those affected. These include the liver itself (nonalcoholic steatohepatitis or NASH; fibrosis and cirrhosis, and hepatocellular carcinoma) or other organs such as the vessels and the heart (cardiovascular disease) or the islets of Langerhans (type 2 diabetes). In addition to elevated caloric intake and a sedentary lifestyle, genetic and epigenetic predisposition contribute to the development of NAFLD and the secondary diseases.

Scope of review

We present data from genome-wide association studies (GWAS) and functional studies in rodents which describe polymorphisms identified in genes r

SUBMITTER: Jonas W 

PROVIDER: S-EPMC8324682 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature