Nonalcoholic fatty liver disease (NAFLD) from pathogenesis to treatment concepts in humans.

ABSTRACT:

Background

Nonalcoholic fatty liver disease (NAFLD) comprises hepatic alterations with increased lipid accumulation (steatosis) without or with inflammation (nonalcoholic steatohepatitis, NASH) and/or fibrosis in the absence of other causes of liver disease. NAFLD is developing as a burgeoning health challenge, mainly due to the worldwide obesity and diabetes epidemics.

Scope of review

This review summarizes the knowledge on the pathogenesis underlying NAFLD by focusing on studies in humans and on hypercaloric nutrition, including effects of saturated fat and fructose, as well as adipose tissue dysfunction, leading to hepatic lipotoxicity, abnormal mitochondrial function, and oxidative stress, and highlights intestinal dysbiosis. These mechanisms are discussed in the context

SUBMITTER: Pafili K 

PROVIDER: S-EPMC8324683 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature