Nuclear receptors and transcriptional regulation in non-alcoholic fatty liver disease.

ABSTRACT:

Background

As a result of a sedentary lifestyle and excess food consumption in modern society, non-alcoholic fatty liver disease (NAFLD) characterized by fat accumulation in the liver is becoming a major disease burden. Non-alcoholic steatohepatitis (NASH) is an advanced form of NAFLD characterized by inflammation and fibrosis that can lead to hepatocellular carcinoma and liver failure. Nuclear receptors (NRs) are a family of ligand-regulated transcription factors that closely control multiple aspects of metabolism. Their transcriptional activity is modulated by various ligands, including hormones and lipids. NRs serve as potential pharmacological targets for NAFLD/NASH and other metabolic diseases.

Scope of review

In this review, we provide a comprehensive overview of NRs t

SUBMITTER: Xiao Y 

PROVIDER: S-EPMC8324695 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature