Three challenging cases of infections by multidrug-resistant Serratia marcescens in patients admitted to intensive care units.

ABSTRACT: The occurrence of multidrug-resistant Serratia marcescens strains represents a serious public health threat. The purpose here is to report three cases of carbapenem-resistant S. marcescens infections with unfavorable clinical outcomes and provide a molecular description of the antibiotic resistance determinants at a genomic level. We performed bacterial identification by VITEK 2 and MALDI-TOF. The minimal inhibitory concentrations of antimicrobials were determined according to the Clinical and Laboratory Standards Institute guidelines, except for tigecycline, for which they were determined using Etest strips. Preliminary screening for the presence of carbapenemases was performed by ertapenem hydrolysis using MALDI-TOF MS. Whole-genome sequencing was provided to identify genes responsible f

SUBMITTER: da Silva KE 

PROVIDER: S-EPMC8324748 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature