Direction of association between Cardiovascular risk and depressive symptoms during the first 18 years of life: A prospective birth cohort study.

ABSTRACT:

Background

Cardiovascular disease (CVD) and depression are bidirectionally associated in adults. However, the direction of association between CVD risk and depressive symptoms in young people and potential mechanisms are poorly understood.

Methods

Using longitudinal birth cohort data, we created a CVD risk score age at 15 using age, ethnicity, physical activity, maternal social status, maternal smoking, own smoking, BMI, systolic blood pressure, LDL, HDL and triglycerides. We used regression analysis to test: (1) association between CVD risk score at age 15 and depressive symptoms at ages 12 and 18; (2) association of IL-6 and CRP at age 9 with depressive symptoms at age 12 and CVD risk score at age 15; and (3) mediating effects of CVD risk score on associations of IL-6/CRP

SUBMITTER: Chaplin AB 

PROVIDER: S-EPMC8324768 | biostudies-literature | 2021 Sep

REPOSITORIES: biostudies-literature