Stress-primed secretory autophagy promotes extracellular BDNF maturation by enhancing MMP9 secretion.

ABSTRACT: The stress response is an essential mechanism for maintaining homeostasis, and its disruption is implicated in several psychiatric disorders. On the cellular level, stress activates, among other mechanisms, autophagy that regulates homeostasis through protein degradation and recycling. Secretory autophagy is a recently described pathway in which autophagosomes fuse with the plasma membrane rather than with lysosomes. Here, we demonstrate that glucocorticoid-mediated stress enhances secretory autophagy via the stress-responsive co-chaperone FK506-binding protein 51. We identify the matrix metalloproteinase 9 (MMP9) as one of the proteins secreted in response to stress. Using cellular assays and in vivo microdialysis, we further find that stress-enhanced MMP9 secretion increases the cleavage

SUBMITTER: Martinelli S 

PROVIDER: S-EPMC8324795 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature