ZBTB32 performs crosstalk with the glucocorticoid receptor and is crucial in glucocorticoid responses to starvation.

ABSTRACT: The hypothalamic-pituitary-adrenal (HPA) axis forms a complex neuroendocrine system that regulates the body's response to stress such as starvation. In contrast with the glucocorticoid receptor (GR), Zinc finger and BTB domain containing 32 (ZBTB32) is a transcription factor with poorly described functional relevance in physiology. This study shows that ZBTB32 is essential for the production of glucocorticoids (GCs) in response to starvation, since ZBTB32^-/- mice fail to increase their GC production in the absence of nutrients. In terms of mechanism, GR-mediated upregulation of adrenal Scarb1 gene expression was absent in ZBTB32^-/- mice, implicating defective cholesterol import as the cause of the poor GC synthesis. These lower GC levels are further associated

SUBMITTER: Van Wyngene L 

PROVIDER: S-EPMC8324811 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature