Plasmodium falciparum transcription in different clinical presentations of malaria associates with circulation time of infected erythrocytes.

ABSTRACT: Following Plasmodium falciparum infection, individuals can remain asymptomatic, present with mild fever in uncomplicated malaria cases, or show one or more severe malaria symptoms. Several studies have investigated associations between parasite transcription and clinical severity, but no broad conclusions have yet been drawn. Here, we apply a series of bioinformatic approaches based on P. falciparum's tightly regulated transcriptional pattern during its ~48-hour intraerythrocytic developmental cycle (IDC) to publicly available transcriptomes of parasites obtained from malaria cases of differing clinical severity across multiple studies. Our analysis shows that within each IDC, the circulation time of infected erythrocytes without sequestering to endothelial cells decreases with increasing

SUBMITTER: Thomson-Luque R 

PROVIDER: S-EPMC8324851 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature