Association of SNPs in GC and CYP2R1 with total and directly measured free 25-hydroxyvitamin D in multi-ethnic postmenopausal women in Saudi Arabia.

ABSTRACT:

Background

Group-specific component (GC) and cytochrome P450 Family 2 Subfamily R Member 1 (CYP2R1) genes are one of the vital genes involved in the vitamin D (vitD) metabolic pathway. Association of genetic polymorphisms in these two genes with 25-hyroxyvitamin D (25(OH)D) level has been reported in several studies. However, this association has been reported to be discrepant among populations from different ethnicities. Therefore, we aimed in this study to investigate association of the two major single nucleotide polymorphisms (SNP) in GC (rs4588 and rs7014) and a SNP (rs12794714) in CYP2R1 in postmenopausal women in Saudi Arabia.

Methods

This study randomly selected 459 postmenopausal women (aged ≥50 years) of multiple ethnicities in Jeddah, S

SUBMITTER: Alharazy S 

PROVIDER: S-EPMC8324961 | biostudies-literature | 2021 Aug

REPOSITORIES: biostudies-literature