Heritability of Functional Connectivity in Resting State: Assessment of the Dynamic Mean, Dynamic Variance, and Static Connectivity across Networks.

ABSTRACT: Recent efforts to evaluate the heritability of the brain's functional connectome have predominantly focused on static connectivity. However, evaluating connectivity changes across time can provide valuable insight about the inherent dynamic nature of brain function. Here, the heritability of Human Connectome Project resting-state fMRI data was examined to determine whether there is a genetic basis for dynamic fluctuations in functional connectivity. The dynamic connectivity variance, in addition to the dynamic mean and standard static connectivity, was evaluated. Heritability was estimated using Accelerated Permutation Inference for the ACE (APACE), which models the additive genetic (h2), common environmental (c2), and unique environmental (e2) variance. Heritability was moderate (mean h2:

SUBMITTER: Barber AD 

PROVIDER: S-EPMC8325018 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature